Shiitake mushroom is a basidiomycete of the genus Lentinus in the family Pleurotaceae. It contains a variety of effective medicinal components. For thousands of years, shiitake mushrooms have been used as a rich source of medicine to treat various diseases. Studies in recent years have shown that shiitake mushroom extract has many biological functions such as anti-virus, anti-bacteria, anti-tumor and immune function regulation. Lentinan has the functions of anti-tumor, treating liver and protecting the liver, and enhancing the body's immunity. Lentinan has the functions of activating cellular immunity, regulating various humoral immune factors, and inducing the production of α-interferon. It can regulate the body's immune response, induce leukocytes to infiltrate tumors, cause blood vessels to dilate, hemorrhage, and necrosis at the tumor site, and prevent virus from binding to host cells.
2. Antiviral effect of shiitake mushroom extract
In recent years, researchers have conducted a lot of research on the antiviral properties of shiitake mushroom extracts. Studies have shown that: shiitake mushroom extracts have good antiviral efficacy, almost no toxic and side effects, and are natural medicines worthy of clinical promotion. It was observed that the extract of shiitake mushrooms has obvious inhibitory effect on herpes simplex virus. The experiment took the proliferation of HSV-1 and HSV-2 on human amnion cells as a model, and the pharmacodynamics of lentinan in inhibiting herpes simplex virus by tissue cell culture method. to discuss. The results show that lentinan has obvious protective effect on cells infected by HSV-1 and HSV-2 viruses, can inhibit and delay the occurrence of cytopathic changes, and the protection rate of virus-infected cells can reach 89.4%, and there is no obvious toxic side effects.
Shiitake mushroom extract also has the same effect on influenza virus, and its protection rate against virus-infected cells can reach 95.6%. Experiments have shown that shiitake mushroom extract has a certain preventive effect on Coxsackie Group B virus, and it can affect certain links in the adsorption and penetration of Coxsackie Group B virus, so that cells can be protected to a certain extent. The combined application of lamivudine and shiitake mushroom extract in the treatment of chronic hepatitis B showed no significant difference in the negative conversion rate of serum hepatitis B virus deoxyribose nucleic acid between the observation group and the control group (94% vs. 89%, P >0.05), the HBeAg negative conversion rate was significantly higher than that of the control group (56% vs. 22%, P<0.01), and the normalization rate of liver function was also significantly higher than that of the control group (99% vs. Obvious adverse reactions were found. Therefore, it is concluded that lentinan can assist in the treatment of hepatitis B virus with good safety.
From the above research results, it can be seen that the antiviral mechanism of shiitake mushroom extract may lie in its functions of improving the immunity of infected cells, increasing the stability of cell membranes, inhibiting cell lesions, and promoting cell repair. Therefore, shiitake mushroom extract shows strong antiviral effect, and is an antiviral health care drug to be developed.
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